CRC ranks third in the list of most diagnosed cancers worldwide. It arises as a consequence of genetic alterations that accumulate over time in the cells lining the large intestine. This ultimately results in their uncontrolled proliferation and malignant transformation. But how do other cells (including immune cells), located within and around a tumour, contribute to CRC onset and development?
“Since studies which clarify the roles of different cells neighbouring tumour cells are scarce, we wanted to shed light on how CRC emerges and progresses by looking beyond just the cancer cell,” says Jessica Roelands, Postdoctoral researcher at the LUMC Department of Pathology.
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